Cetilar® & CFAs

What are CFAs?

CFAs are Cetylated Fatty Acids. What this means is that they are fatty acids that have been esterified with cetyl alcohol. The reason this is done is to help the fatty acids penetrate deeper into the body to be more effective. (For example, regular fatty acids cannot go through your skin, but the process of esterification allows CFAs to penetrate the skin, which allows them to be applied topically.)1,2

What are CFAs used for?

CFAs are used to help with pain, arthritis, increase range of motion, improve muscle strength, and reduce inflammation. Research has shown that they can help with recovery of sports injuries as well. They can be used as a topical CFA cream, capsules, or topical patches.1,2,5

How do CFAs work?

“CFAs are believed to reduce pain by decreasing the secretion of leukotriene B4 from stimulated neutrophils, diminishing the release of IL-1 by monocytes, and ultimately reducing the production of IL-6, TNF, and MCP-1.”3,4

In layman’s terms, CFAs help to reduce the production of key regulators of the inflammatory process in the body.

Why is this significant? Because chronic inflammation is the root cause of most chronic pain and conditions (such as Type II Diabetes, heart disease, metabolic syndrome, autoimmune conditions, and cancer). People’s bodies get stuck in a inflammatory feedback loop, so their bodies are being constantly damaged by unmitigated inflammation.

(FYI – some inflammation is good. If it wasn’t, it would not be a mechanism in your body. Acute inflammation, aka, your body’s response to trauma is the critical first step to healing. The problem is that the inflammation process is supposed to resolve/stop, not continue forever like in chronic inflammation. Turns out that OTC pain management drugs like ibuprofen block the resolution pathways – so you get short term relief but long-term problems.)

Are CFAs safe?

Studies have found that CFAs are safe. Lipocet®, the blend of CFAs in Cetilar® Oro, has been demonstrated to be safe. “4,500 mg/kg body weight/day (the highest dose tested) was considered the no-observed-adverse-effect-level. These results support the safety of Lipocet® for use as a food ingredient.”6,7

How to use Cetilar® Oro?

Our recommendation is to take 2 sachets of Cetilar® Oro per day for 10 days, then 1 sachet per day for 60 days. It takes on average 60-90 days for your body to turn over cells and heal.

Steve and I noticed improvements in our arthritis pain within 2 days of starting the program, so we hope you see similar results!

If you are interested in trying Cetilar® Oro, or any of their topical products, please contact us at 978-237-5106 or by email at [email protected].

Written by: Dr. Janine Pulley

January 3, 2024

* Disclaimer: As always, consult your healthcare practitioner to see which supplements and their dosages would be best for you and your condition. All supplements are contraindicated during pregnancy and lactation unless otherwise directed by a qualified healthcare professional you are under current care with.

Patient Information Leaflet: https://www.pharmanutra.it/wp-content/uploads/2022/07/Cetilar-Oro-foglietto-web.pdf

Cetilar Oro Science Page: https://www.cetilar.com/en/scienza/



  1. Sharan D, Jacob BN, Ajeesh PS, Bookout JB, Carathur RR. The effect of cetylated fatty esters and physical therapy on myofascial pain syndrome of the neck. J Bodyw Mov Ther. 2011;15(3):363-374. https://pubmed.ncbi.nlm.nih.gov/21665114/
  2. Ariani A, Parisi S, Guidelli GM, Bardelli M, Bertini A, Fusaro E. Short-Term Effect of Topical Cetylated Fatty Acid on Early and Advanced Knee Osteoarthritis: A Multi-Center Study. Arch Rheumatol. 2018;33(4):438-442.
  3. Pelak A, Barve A, Carroll K, Madrazo-Ibarra A, Vad V. Effect of Cetylated Fatty Acid Supplementation on Axial Discogenic Low Back Pain. Int J Phys Med Rehabil. 2023;11:662.
  4. Hudita A, Galateanu B, Dinescu S, Costache M, Dinischiotu A, Negrei C, Stan M, Tsatsakis A, Nikitovic D, Lupuliasa D, Balanescu A. In Vitro Effects of Cetylated Fatty Acids Mixture from Celadrin on Chondrogenesis and Inflammation with Impact on Osteoarthritis. Cartilage. 2020 Jan;11(1):88-97. doi: 10.1177/1947603518775798. Epub 2018 May 29. PMID: 29808705; PMCID: PMC6921950.
  5. Lanzisera R, Baroni A, Lenti G, Geri E. A prospective observational study on the beneficial effects and tolerability of a cetylated fatty acids (CFA) complex in a patch formulation for shoulder tendon disorders. BMC Musculoskelet Disord. 2022 Apr 12;23(1):352. doi: 10.1186/s12891-022-05304-x. PMID: 35413878; PMCID: PMC9003972. https://pubmed.ncbi.nlm.nih.gov/35413878/
  6. Brilli E, Tarantino G. Genotoxicity and subchronic toxicity studies of Lipocet®, a novel mixture of cetylated fatty acids. J Appl Toxicol. 2021 Jul;41(7):1148-1162. doi: 10.1002/jat.4101. Epub 2020 Nov 3. PMID: 33145810.
  7. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA); Turck D, Castenmiller J, De Henauw S, Hirsch-Ernst KI, Kearney J, Maciuk A, Mangelsdorf I, McArdle HJ, Naska A, Pelaez C, Pentieva K, Siani A, Thies F, Tsabouri S, Vinceti M, Cubadda F, Engel KH, Frenzel T, Heinonen M, Marchelli R, Neuhäuser-Berthold M, Poulsen M, Sanz Y, Schlatter JR, van Loveren H, Gelbmann W, Knutsen HK. Safety of Cetylated Fatty Acids as a Novel Food pursuant to Regulation (EU) 2015/2283. EFSA J. 2021 Jul 21;19(7):e06670. doi: 10.2903/j.efsa.2021.6670. PMID: 34306218; PMCID: PMC8294049.